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Comparison of Bioavailability and Pharmacokinetics of Diclofenac Sodium and Diclofenac Potassium in Healthy and Escherichia Coli Induced Febrile Rabbits (Report)

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Title: Comparison of Bioavailability and Pharmacokinetics of Diclofenac Sodium and Diclofenac Potassium in Healthy and Escherichia Coli Induced Febrile Rabbits (Report)
Author : Pakistan Journal of Zoology
Release Date : January 31, 2010
Genre: Life Sciences,Books,Science & Nature,
Pages : * pages
Size : 206 KB

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Byline: Mahmood Ahmad, Muhammad Iqbal, Naveed Akhtar, Ghulam Murtaza , Muhammad Asadullah Madni and Fatima Rasool - Email:gmdogar356@gmail.com Abstract.- Diclofenac sodium and diclofenac potassium in tablet dosage form were tested for their bioavailability and disposition kinetics in a group of 18 rabbits in normal and Escherichia coli induced febrile condition with a washout period of 7 days. Biochemical and physiological parameters were measured in both normal and febrile state. Diclofenac levels in plasma were determined using a reversed-phase HPLC method. Primary kinetic parameters i.e. AUC0-8, Cmax, tmax and other disposition kinetics, were obtained with non-compartmental procedure. The values of physiological and biochemical parameter were significantly (p0.05) low in febrile rabbits as compared to that of normal animals.