(DOWNLOAD) "Comparison of Five Thrombin Time Reagents (Technical Briefs)" by Clinical Chemistry * Book PDF Kindle ePub Free
eBook details
- Title: Comparison of Five Thrombin Time Reagents (Technical Briefs)
- Author : Clinical Chemistry
- Release Date : January 01, 2003
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 162 KB
Description
The thrombin time (TT) assay is a core test in clinical laboratories that perform coagulation testing. This assay screens for abnormalities in the conversion of fibrinogen to fibrin. The time necessary for fibrinogen to clot is affected by hypofibrinogenemia, dysfibrinogenemia, and the presence of inhibitors of the fibrinogen-to-fibrin reaction (heparin, hirudin, fibrin degradation products, and paraproteins) (1). The TT is used primarily to evaluate plasma specimens with prolonged activated partial thromboplastin time (APTT) values and, to a lesser extent, prolonged prothrombin time (PT) values for heparin or other thrombin inhibitors. The test is also useful to detect quantitative and qualitative fibrinogen abnormalities. Important criteria for selecting a TT reagent are high sensitivity to heparin, sensitivity to hypofibrinogenemia, and acceptable precision. We compared five commercial TT reagents on our automated coagulation analyzer and evaluated their sensitivity to fibrinogen and heparin concentration, their precision, and their accuracy.