[Download] "Comparison of Methods for the Detection of Oligoclonal Igg Bands in Cerebrospinal Fluid and Serum: Results of the Dutch Quality Control Survey (Technical Briefs)" by Clinical Chemistry ~ Book PDF Kindle ePub Free
eBook details
- Title: Comparison of Methods for the Detection of Oligoclonal Igg Bands in Cerebrospinal Fluid and Serum: Results of the Dutch Quality Control Survey (Technical Briefs)
- Author : Clinical Chemistry
- Release Date : January 01, 2002
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 198 KB
Description
Detection of oligoclonal IgG bands (OCBs) in parallel cerebrospinal fluid (CSF) and serum samples is an important tool to support the diagnosis of neuroinflammatory diseases such as multiple sclerosis (MS) (1). Because ~90-95% of the patients diagnosed with MS present with OCBs in the CSF (2), whereas other CSF indices may be normal, this type of analysis has long been recommended for the diagnosis of MS, especially when the clinical presentation does not clearly suggest this diagnosis (1,3). CSF-restricted OCBs are also essential for the diagnosis of primary progressive MS (1). Furthermore, in several neuroimmunologic disorders, including neuroborrehosis, neurosyphilis, and viral infections of the brain, the identification of OCBs in CSF may be helpful in the diagnostic process (2, 4,5). Twice a year, pairs of CSF and serum samples are distributed by our laboratories to the participants of the Dutch CSF Quality Control survey for analysis of OCBs. It was the aim of this study to evaluate the performance of the 56 participating laboratories for OCB analysis with regard to both the methods used for protein separation and detection of OCBs and to derive a general recommendation on laboratory management for this type of analysis.